Statin Signaling

Statins represent a class of lipid lowering drugs developed for the treatment of cardiovascular disease. Inhibition of hydroxymethylglutaryl coenzyme A reductase (HMGCR), a key enzyme of the mevalonate pathway, by statin drugs results in pleiotropic effects. In addition to a positive effect in reducing serum cholesterol, statins have proven to have some activity as anticancer agents and may be useful for the treatment of other diseases, likely through the effects of statins on several other cellular pathways including MAPK, NFKB, AKT, PPAR, apoptosis and inflammatory signaling. This Statin signaling PCR primer library contains primer sets directed not only at the genes regulating the mevalonate pathway, but include many of the downstream effector molecules that are up- and down-regulated following statin exposure.