Cancer arises from the accumulation of genetic and epigenetic changes that disrupt normal control of cell growth and survival. These changes affect the hallmark pathways of cancer, including sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, angiogenesis, invasion and metastasis, altered metabolism and immune evasion. Key genes include oncogenes such as MYC, RAS and ERBB2, tumor suppressors such as TP53, RB1 and PTEN, and regulators of the cell cycle, apoptosis, DNA repair and angiogenesis.
A ready-to-use Human Cancer Pathway PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against cancer-associated genes and 8 housekeeping gene primer sets. Provided in a 96-well microplate (20 l - 10 M) Perform up to 100 PCR arrays (based on 20 l assay volume per reaction) Just add cDNA template and SYBR green master mix GENE LIST: AKT1 v-akt murine thymoma viral oncogene homolog 1 AKT2 v-akt murine thymoma viral oncogene homolog 2 AKT3 v-akt murine thymoma viral oncogene homolog 3 ANGPT1 angiopoietin 1 APAF1 apoptotic peptidase activating factor 1 ATM ataxia telangiectasia mutated BAD BCL2-associated agonist of cell death BAX BCL2-associated X protein BCL2 B-cell CLL/lymphoma 2 BCL2L1 BCL2-like 1 BIRC5 baculoviral IAP repeat containing 5 BRCA1 breast cancer 1, early onset BRCA2 breast cancer 1, early onset CASP8 caspase 8, apoptosis-related cysteine peptidase CCND1 cyclin D1 CCNE1 cyclin E1 CDC25A cell division cycle 25 homolog A (S. pombe) CDH1 cadherin 1, type 1, E-cadherin (epithelial) CDK2 cyclin-dependent kinase 2 CDK4 cyclin-dependent kinase 4 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN2A cyclin-dependent kinase inhibitor 2A CFLAR CASP8 and FADD-like apoptosis regulator CHEK1 checkpoint kinase 1 CHEK2 checkpoint kinase 2 COL18A1 collagen, type XVIII, alpha 1 CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa E2F1 E2F transcription factor 1 EGFR epidermal growth factor receptor ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) FAS Fas (TNF receptor superfamily, member 6) FGF1 fibroblast growth factor 1 (acidic) FGFR2 fibroblast growth factor receptor 2 FIGF c-fos induced growth factor (vascular endothelial growth factor D) FOS FBJ murine osteosarcoma viral oncogene homolog GRB2 growth factor receptor-bound protein 2 HGF hepatocyte growth factor (hepapoietin A; scatter factor) IFNB1 interferon, beta 1, fibroblast IGF1 insulin-like growth factor 1 (somatomedin C) ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) ITGAV integrin, alpha V ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) JUN jun proto-oncogene KISS1 KiSS-1 metastasis-suppressor MAP2K1 mitogen-activated protein kinase kinase 1 MCAM melanoma cell adhesion molecule MDM2 Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) MET met proto-oncogene (hepatocyte growth factor receptor) MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) MTA1 metastasis associated 1 MTA2 metastasis associated 1 family, member 2 MUC1 mucin 1, cell surface associated MYC V-myc myelocytomatosis viral oncogene homolog (avian) NCAM1 neural cell adhesion molecule 1 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha NME4 NME/NM23 nucleoside diphosphate kinase 4 PDGFA platelet-derived growth factor alpha polypeptide PDGFB platelet-derived growth factor beta polypeptide PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) PLAU plasminogen activator, urokinase PLAUR plasminogen activator, urokinase receptor PTEN phosphatase and tensin homolog RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 RB1 retinoblastoma 1 RELA V-rel reticuloendotheliosis viral oncogene homolog A S100A4 S100 calcium binding protein A4 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 SERPNB2 Data not found SYK spleen tyrosine kinase TEK TEK tyrosine kinase, endothelial TERT telomerase reverse transcriptase TGFB1 transforming growth factor, beta 1 TGFBR1 transforming growth factor, beta receptor 1 THBS1 thrombospondin 1 TIMP1 TIMP metallopeptidase inhibitor 1 TNF tumor necrosis factor TNFRSF10B tumor necrosis factor receptor superfamily, member 10b TNFRSF1A tumor necrosis factor receptor superfamily, member 1A TP53 tumor protein p53 TWIST1 twist homolog 1 (Drosophila) VEGFA vascular endothelial growth factor A VEGFB vascular endothelial growth factor B VEGFC vascular endothelial growth factor C ACTB Actin, beta B2M Beta-2-microglobulin GAPDH Glyceraldehyde-3-phosphate dehydrogenase GUSB Glucuronidase, beta HPRT1 Hypoxanthine phosphoribosyltransferase 1 PGK1 Phosphoglycerate kinase 1 PPIA Peptidylprolyl isomerase A RPL13A Ribosomal protein L13a $495.00 |