Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by differences in social communication and by restricted, repetitive behaviors. ASD has a strong genetic component, and many of the genes implicated encode proteins involved in synapse formation and function, neuronal signaling, chromatin remodeling and transcriptional regulation. Examples include synaptic scaffolding and adhesion genes such as SHANK3, NLGN3, NLGN4X and NRXN1, as well as regulators such as MECP2, FMR1, PTEN, TSC1/TSC2 and CHD8. Gene expression profiling helps researchers explore how these networks are altered in neuronal and other cell models of ASD.
A ready-to-use Human Autism AI PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against autism genes and 8 housekeeping gene primer sets. Provided in a 96-well microplate (20 ul - 10 uM) Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction) Just add cDNA template and SYBR green master mix GENE LIST: ANK2 ankyrin 2, neuronal ANK3 ankyrin 3, node of Ranvier (ankyrin G) ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 AUTS2 autism susceptibility candidate 2 CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit CACNB2 calcium channel, voltage-dependent, beta 2 subunit CADPS2 Ca++-dependent secretion activator 2 CAMK2A calcium/calmodulin-dependent protein kinase II alpha CAMK2B calcium/calmodulin-dependent protein kinase II beta CBLN1 cerebellin 1 precursor CDH9 cadherin 9, type 2 (T1-cadherin) CHD7 chromodomain helicase DNA binding protein 7 CHD8 chromodomain helicase DNA binding protein 8 CNR1 cannabinoid receptor 1 (brain) CNTN6 contactin 6 CNTNAP2 contactin associated protein-like 2 DLGAP1 discs, large (Drosophila) homolog-associated protein 1 DLGAP2 discs, large (Drosophila) homolog-associated protein 2 DLGAP3 discs, large (Drosophila) homolog-associated protein 3 DLGAP4 discs, large (Drosophila) homolog-associated protein 4 DLGAP5 discs, large (Drosophila) homolog-associated protein 5 DNM1 dynamin 1 DPP10 dipeptidyl-peptidase 10 (non-functional) EHMT1 euchromatic histone-lysine N-methyltransferase 1 FAM135B family with sequence similarity 135, member B FMR1 fragile X mental retardation 1 FOXP1 forkhead box P1 FOXP2 forkhead box P2 FOXP3 forkhead box P3 GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 GRIK2 glutamate receptor, ionotropic, kainate 2 GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B GRM8 glutamate receptor, metabotropic 8 ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) LAMA1 laminin, alpha 1 LAMB1 laminin, beta 1 LAMC1 laminin, gamma 1 (formerly LAMB2) MACF1 microtubule-actin crosslinking factor 1 MAP1B microtubule-associated protein 1B MTHFR methylenetetrahydrofolate reductase (NAD(P)H) NEUROD1 neuronal differentiation 1 NEUROD2 neuronal differentiation 2 NEUROD6 neuronal differentiation 6 NEUROG1 neurogenin 1 NEUROG2 neurogenin 2 NLGN1 neuroligin 1 NLGN3 neuroligin 3 NLGN4X neuroligin 4, X-linked NLGN4Y neuroligin 4, Y-linked NOS1 nitric oxide synthase 1 (neuronal) NOS2 nitric oxide synthase 2, inducible NOS3 nitric oxide synthase 3 (endothelial cell) NRXN1 neurexin 1 OXTR oxytocin receptor PCDH10 protocadherin 10 PCDH19 protocadherin 19 PCDH9 protocadherin 9 PTPRD protein tyrosine phosphatase, receptor type, D RELN reelin RORA RAR-related orphan receptor A SHANK1 SH3 and multiple ankyrin repeat domains 1 SHANK2 SH3 and multiple ankyrin repeat domains 2 SHANK3 SH3 and multiple ankyrin repeat domains 3 SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 SLC9A9 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 9 TBR1 T-box, brain, 1 TSC1 tuberous sclerosis 1 TSC2 tuberous sclerosis 2 UBE3A ubiquitin protein ligase E3A UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) WNT2 wingless-type MMTV integration site family member 2 WNT7A wingless-type MMTV integration site family, member 7A WNT9B wingless-type MMTV integration site family, member 9B YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ZNF804A zinc finger protein 804A ACTB Actin, beta B2M Beta-2-microglobulin GAPD Glyceraldehyde-3-phosphate dehydrogenase GUSB Glucuronidase, beta HPRT1 Hypoxanthine phosphoribosyltransferase 1 PGK Phosphoglycerate kinase 1 PPIA Peptidylprolyl isomerase A RPL13A Ribosomal protein L13a $495.00 |