Ligand gated ion channels are membrane proteins that open an ion pore when a neurotransmitter or other ligand binds, allowing rapid electrical signaling between nerve cells and at the neuromuscular junction. Major families include the nicotinic acetylcholine receptors (CHRN), GABA-A receptors (GABR), glycine receptors (GLR), serotonin 5-HT3 receptors (HTR3), ionotropic glutamate receptors (AMPA, NMDA and kainate; GRIA, GRIN, GRIK) and P2X purinergic receptors. These channels are central to learning, memory and muscle control and are targets for anesthetics, anticonvulsants and anxiolytic drugs.
A ready-to-use Human Ligand Gated Ion Channels PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against ligand-gated ion channel genes and 8 housekeeping gene primer sets. Provided in a 96-well microplate (20 ul - 10 uM) Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction) Just add cDNA template and SYBR green master mix GENE LIST: CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) CHRND cholinergic receptor, nicotinic, delta (muscle) CHRNE cholinergic receptor, nicotinic, epsilon (muscle) CLCN1 chloride channel, voltage-sensitive 1 CLCN2 chloride channel, voltage-sensitive 2 CLCN4 chloride channel, voltage-sensitive 4 CLCN5 chloride channel, voltage-sensitive 5 CLCN6 chloride channel, voltage-sensitive 6 CLCN7 chloride channel, voltage-sensitive 7 CLCNKA chloride channel, voltage-sensitive Ka CLCNKB chloride channel, voltage-sensitive Kb CLIC1 chloride intracellular channel 1 CLIC3 chloride intracellular channel 3 CLIC4 chloride intracellular channel 4 CLIC5 chloride intracellular channel 5 CLIC6 chloride intracellular channel 6 CNGA3 cyclic nucleotide gated channel alpha 3 GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 GABRD gamma-aminobutyric acid (GABA) A receptor, delta GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 GABRP gamma-aminobutyric acid (GABA) A receptor, pi GABRQ gamma-aminobutyric acid (GABA) A receptor, theta GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 GLRA1 glycine receptor, alpha 1 GLRA2 glycine receptor, alpha 2 GLRA3 glycine receptor, alpha 3 GLRB glycine receptor, beta GRIA1 glutamate receptor, ionotropic, AMPA 1 GRIA2 glutamate receptor, ionotropic, AMPA 2 GRIA3 glutamate receptor, ionotropic, AMPA 3 GRIA4 glutamate receptor, ionotropic, AMPA 4 GRID1 glutamate receptor, ionotropic, delta 1 GRID2 glutamate receptor, ionotropic, delta 2 GRIK1 glutamate receptor, ionotropic, kainate 1 GRIK2 glutamate receptor, ionotropic, kainate 2 GRIK3 glutamate receptor, ionotropic, kainate 3 GRIN1 glutamate receptor, ionotropic, N-methyl D- aspartate 1 GRIN2A glutamate receptor, ionotropic, N-methyl D- aspartate 2A GRIN2B glutamate receptor, ionotropic, N-methyl D- aspartate 2B GRIN2D glutamate receptor, ionotropic, N-methyl D- aspartate 2D GRIN3A glutamate receptor, ionotropic, N-methyl-D- aspartate 3A HCN3 hyperpolarization activated cyclic nucleotide- gated potassium channel 3 HCN4 hyperpolarization activated cyclic nucleotide- gated potassium channel 4 HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1 P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2 P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 P2RX4 purinergic receptor P2X, ligand-gated ion channel, 4 P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7 PKD2 polycystic kidney disease 2 (autosomal dominant) PKD2L1 polycystic kidney disease 2-like 1 RYR1 ryanodine receptor 1 (skeletal) RYR2 ryanodine receptor 2 (cardiac) RYR3 ryanodine receptor 3 SCNN1A sodium channel, non-voltage-gated 1 alpha subunit SCNN1B sodium channel, non-voltage-gated 1, beta subunit SCNN1D sodium channel, non-voltage-gated 1, delta subunit SCNN1G sodium channel, non-voltage-gated 1, gamma subunit TRPC1 transient receptor potential cation channel, subfamily C, member 1 TRPC3 transient receptor potential cation channel, subfamily C, member 3 TRPC4 transient receptor potential cation channel, subfamily C, member 4 TRPC5 transient receptor potential cation channel, subfamily C, member 5 TRPC6 transient receptor potential cation channel, subfamily C, member 6 ACTB Housekeeping Gene B2M Housekeeping Gene GAPD Housekeeping Gene GUSB Housekeeping Gene HPRT1 Housekeeping Gene PGK1 Housekeeping Gene PPIA Housekeeping Gene RPL13A Housekeeping Gene $695.00 |