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Cytokine & Chemokine Receptors

Cytokine receptors and chemokine receptors are essential cell surface proteins that bind to their respective signaling molecules, cytokines and chemokines, to transmit messages into a cell. This binding initiates a signal transduction cascade that ultimately dictates the cell's function, particularly in the immune system.

Cytokine Receptors Function: Cytokine receptors bind to cytokines, which are a diverse group of small signaling proteins (like interleukins, interferons, and tumor necrosis factors) that regulate cell activities such as growth, proliferation, differentiation, and inflammation. When a cytokine binds, the receptor complex is activated, triggering internal signaling pathways (often involving Janus kinases (JAKs) and STAT proteins) to change gene expression and cellular behavior.

Structure: They typically have a single transmembrane domain but often function as part of larger receptor complexes formed by multiple chains (subunits) upon ligand binding.

Classification: Cytokine receptors are broadly classified into several families based on their structure and shared signaling components, including:

Type I Cytokine Receptors: Receptors for most Interleukins (like IL-2, IL-4, IL-6) and Colony-Stimulating Factors (CSFs). They lack intrinsic enzyme activity but couple with JAK family kinases.

Type II Cytokine Receptors: Receptors for Interferons (IFNs) and the IL-10 family.

TNF Receptor Superfamily: Receptors for Tumor Necrosis Factor (TNF) and related molecules.

Immunoglobulin (Ig) Superfamily: Receptors like the Interleukin-1 (IL-1) receptor.

Chemokine Receptors Function: Chemokine receptors bind to chemokines (a specific subset of cytokines), which are primarily known for their role as chemoattractants. The main function of this interaction is to induce chemotaxis—the directed movement and migration of cells, most notably leukocytes (white blood cells), to sites of infection, injury, or inflammation. This process is crucial for immune surveillance and the mounting of an immune response.

Structure: Chemokine receptors are members of the G protein-coupled receptor (GPCR) superfamily. They possess a characteristic structure with seven transmembrane domains and are coupled to intracellular G-proteins for signal transduction.

Classification: Chemokine receptors are categorized based on the specific structural class of chemokines (ligands) they bind:

CC Chemokine Receptors (CCR): Bind to CC chemokines (e.g., CCR5).

CXC Chemokine Receptors (CXCR): Bind to CXC chemokines (e.g., CXCR4).

CX3C Chemokine Receptors (CX3CR1) and XC Chemokine Receptors (XCR1), which are minor subfamilies.

In essence, both receptor types coordinate the body's immune, inflammatory, and tissue maintenance responses.. The cytokine and chemokine receptor primer library may be used to set up 100 qPCR arrays (based on a 20 ul reaction).

Human Cytokine and Chemokine Receptor Primer Library
A ready-to-use Human Cytokine and Chemokine Receptor PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against cytokine and chemokine receptor genes and 8 housekeeping gene primer sets.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



GENE LIST:

CCR1 chemokine (C-C motif) receptor 1

CCR2 chemokine (C-C motif) receptor 2

CCR3 chemokine (C-C motif) receptor 3

CCR4 chemokine (C-C motif) receptor 4

CCR5 chemokine (C-C motif) receptor 5

CCR6 chemokine (C-C motif) receptor 6

CCR7 chemokine (C-C motif) receptor 7

CCR8 chemokine (C-C motif) receptor 8

CCR9 chemokine (C-C motif) receptor 9

CCR10 chemokine (C-C motif) receptor 10

CX3CR1 chemokine (C-X3-C motif) receptor 1

CXCR1 chemokine (C-X-C motif) receptor 1

CXCR2 chemokine (C-X-C motif) receptor 2

CXCR3 chemokine (C-X-C motif) receptor 3

CXCR4 chemokine (C-X-C motif) receptor 4

CXCR5 chemokine (C-X-C motif) receptor 5

XCR1 chemokine (C motif) receptor 1

IL1R1 interleukin 1 receptor, type I

IL1R2 interleukin 1 receptor, type II

IL1RAP interleukin 1 receptor accessory protein

IL1RAPL1 interleukin 1 receptor accessory protein- like 1

IL1RAPL2 interleukin 1 receptor accessory protein- like 2

IL1RL1 interleukin 1 receptor-like 1

IL1RL2 interleukin 1 receptor-like 2

IL1RN interleukin 1 receptor antagonist

IL2RA interleukin 2 receptor, alpha

IL2RB interleukin 2 receptor, beta

IL2RG interleukin 2 receptor, gamma

IL3RA interleukin 3 receptor, alpha

IL4R interleukin 4 receptor

IL5RA interleukin 5 receptor, alpha

IL6R interleukin 6 receptor

IL6ST interleukin 6 signal transducer

IL7R interleukin 7 receptor

IL9R interleukin 9 receptor

IL10RA interleukin 10 receptor, alpha

IL10RB interleukin 10 receptor, beta

IL11RA interleukin 11 receptor, alpha

IL11RB interleukin 11 receptor, beta

IL12RB1 interleukin 12 receptor, beta 1

IL12RB2 interleukin 12 receptor, beta 2

IL13RA1 interleukin 13 receptor, alpha 1

IL13RA2 interleukin 13 receptor, alpha 2

IL15RA interleukin 15 receptor, alpha

IL15RB interleukin 15 receptor, beta

IL17RA interleukin 17 receptor A

IL17RB interleukin 17 receptor B

IL17RC interleukin 17 receptor C

IL17RD interleukin 17 receptor D

IL17RE interleukin 17 receptor E

IL18R1 interleukin 18 receptor 1

IL18RAP interleukin 18 receptor accessory protein

IL20RA interleukin 20 receptor, alpha

IL20RB interleukin 20 receptor beta

IL21R interleukin 21 receptor

IL22RA1 interleukin 22 receptor, alpha 1

IL22RA2 interleukin 22 receptor, alpha 2

IL27RA interleukin 27 receptor, alpha

IL28RA interleukin 28 receptor, alpha

IL31RA interleukin 31 receptor, alpha

CD40 CD40 molecule, TNF receptor superfamily member 5

FAS Fas (TNF receptor superfamily, member 6)

LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)

NGFR nerve growth factor receptor (TNFR superfamily, member 16)

TNFRSF1A tumor necrosis factor receptor superfamily, member 1A

TNFRSF1B tumor necrosis factor receptor superfamily, member 1B

TNFRSF4 tumor necrosis factor receptor superfamily, member 4

TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy

TNFRSF7 tumor necrosis factor receptor superfamily, member 7

TNFRSF8 tumor necrosis factor receptor superfamily, member 8

TNFRSF9 tumor necrosis factor receptor superfamily, member 9

TNFRSF10A tumor necrosis factor receptor superfamily, member 10a

TNFRSF10B tumor necrosis factor receptor superfamily, member 10b

TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain

TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator

TNFRSF11B tumor necrosis factor receptor superfamily, member 11b

TNFRSF12A tumor necrosis factor receptor superfamily, member 12A

TNFRSF13B tumor necrosis factor receptor superfamily, member 13B

TNFRSF13C tumor necrosis factor receptor superfamily, member 13C

TNFRSF14 tumor necrosis factor receptor superfamily, member 14

TNFRSF17 tumor necrosis factor receptor superfamily, member 17

TNFRSF18 tumor necrosis factor receptor superfamily, member 18

TNFRSF19 tumor necrosis factor receptor superfamily, member 19

TNFRSF21 tumor necrosis factor receptor superfamily, member 21

TNFRSF25 tumor necrosis factor receptor superfamily, member 25

ACTB Actin, beta

B2M Beta-2-microglobulin

GAPDH Glyceraldehyde-3-phosphate dehydrogenase

GUSB Glucuronidase, beta

HPRT1 Hypoxanthine phosphoribosyltransferase 1

PGK1 Phosphoglycerate kinase 1

PPIA Peptidylprolyl isomerase A

RPL13A Ribosomal protein L13a

$595.00
HCCR-I
Mouse Cytokine and Chemokine Receptor Primer Library
A ready-to-use Mouse Cytokine and Chemokine Receptor PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against cytokine and chemokine receptor genes and 8 housekeeping gene primer sets.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



GENE LIST:

Ccr1 chemokine (C-C motif) receptor 1

Ccr2 chemokine (C-C motif) receptor 2

Ccr3 chemokine (C-C motif) receptor 3

Ccr4 chemokine (C-C motif) receptor 4

Ccr5 chemokine (C-C motif) receptor 5

Ccr6 chemokine (C-C motif) receptor 6

Ccr7 chemokine (C-C motif) receptor 7

Ccr8 chemokine (C-C motif) receptor 8

Ccr9 chemokine (C-C motif) receptor 9

Ccr10 chemokine (C-C motif) receptor 10

Cx3Cr1 chemokine (C-X3-C motif) receptor 1

Cxcr1 chemokine (C-X-C motif) receptor 1

Cxcr2 chemokine (C-X-C motif) receptor 2

Cxcr3 chemokine (C-X-C motif) receptor 3

Cxcr4 chemokine (C-X-C motif) receptor 4

Cxcr5 chemokine (C-X-C motif) receptor 5

Xcr1 chemokine (C motif) receptor 1

Il1R1 interleukin 1 receptor, type I

Il1R2 interleukin 1 receptor, type II

Il1Rap interleukin 1 receptor accessory protein

Il1Rapl1 interleukin 1 receptor accessory protein- like 1

Il1Rapl2 interleukin 1 receptor accessory protein- like 2

Il1Rl1 interleukin 1 receptor-like 1

Il1Rl2 interleukin 1 receptor-like 2

Il1Rn interleukin 1 receptor antagonist

Il2Ra interleukin 2 receptor, alpha

Il2Rb interleukin 2 receptor, beta

Il2Rg interleukin 2 receptor, gamma

Il3Ra interleukin 3 receptor, alpha

Il4R interleukin 4 receptor

Il5Ra interleukin 5 receptor, alpha

Il6R interleukin 6 receptor

Il6St interleukin 6 signal transducer

Il7R interleukin 7 receptor

Il9R interleukin 9 receptor

Il10Ra interleukin 10 receptor, alpha

Il10Rb interleukin 10 receptor, beta

Il11Ra interleukin 11 receptor, alpha

Il11Rb interleukin 11 receptor, beta

Il12Rb1 interleukin 12 receptor, beta 1

Il12Rb2 interleukin 12 receptor, beta 2

Il13Ra1 interleukin 13 receptor, alpha 1

Il13Ra2 interleukin 13 receptor, alpha 2

Il15Ra interleukin 15 receptor, alpha

Il15Rb interleukin 15 receptor, beta

Il17Ra interleukin 17 receptor A

Il17Rb interleukin 17 receptor B

Il17Rc interleukin 17 receptor C

Il17Rd interleukin 17 receptor D

Il17Re interleukin 17 receptor E

Il18R1 interleukin 18 receptor 1

Il18Rap interleukin 18 receptor accessory protein

Il20Ra interleukin 20 receptor, alpha

Il20Rb interleukin 20 receptor beta

Il21R interleukin 21 receptor

Il22Ra1 interleukin 22 receptor, alpha 1

Il22Ra2 interleukin 22 receptor, alpha 2

Il27Ra interleukin 27 receptor, alpha

Il28Ra interleukin 28 receptor, alpha

Il31Ra interleukin 31 receptor, alpha

Cd40 CD40 molecule, TNF receptor superfamily member 5

Fas Fas (TNF receptor superfamily, member 6)

Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3)

Ngfr nerve growth factor receptor (TNFR superfamily, member 16)

Tnfrsf1A tumor necrosis factor receptor superfamily, member 1A

Tnfrsf1B tumor necrosis factor receptor superfamily, member 1B

Tnfrsf4 tumor necrosis factor receptor superfamily, member 4

Tnfrsf6B tumor necrosis factor receptor superfamily, member 6b, decoy

Tnfrsf7 tumor necrosis factor receptor superfamily, member 7

Tnfrsf8 tumor necrosis factor receptor superfamily, member 8

Tnfrsf9 tumor necrosis factor receptor superfamily, member 9

Tnfrsf10A tumor necrosis factor receptor superfamily, member 10a

Tnfrsf10B tumor necrosis factor receptor superfamily, member 10b

Tnfrsf10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

Tnfrsf10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain

Tnfrsf11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Tnfrsf11B tumor necrosis factor receptor superfamily, member 11b

Tnfrsf12A tumor necrosis factor receptor superfamily, member 12A

Tnfrsf13B tumor necrosis factor receptor superfamily, member 13B

Tnfrsf13C tumor necrosis factor receptor superfamily, member 13C

Tnfrsf14 tumor necrosis factor receptor superfamily, member 14

Tnfrsf17 tumor necrosis factor receptor superfamily, member 17

Tnfrsf18 tumor necrosis factor receptor superfamily, member 18

Tnfrsf19 tumor necrosis factor receptor superfamily, member 19

Tnfrsf21 tumor necrosis factor receptor superfamily, member 21

Tnfrsf25 tumor necrosis factor receptor superfamily, member 25

Actb Actin, beta

B2M Beta-2-microglobulin

Gapdh Glyceraldehyde-3-phosphate dehydrogenase

Gusb Glucuronidase, beta

Hprt1 Hypoxanthine phosphoribosyltransferase 1

Pgk1 Phosphoglycerate kinase 1

Ppia Peptidylprolyl isomerase A

Rpl13A Ribosomal protein L13a
$595.00
MCCR-I