Cuproptosis

Contains 88 primer sets directed against cuproptosis genes and 8 housekeeping gene primer sets.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix

GENE LIST:

Cuproptosis is a form of regulated cell death that is fundamentally different from other known types, such as apoptosis, ferroptosis, necroptosis, or pyroptosis. It is triggered by excessive intracellular copper accumulation and is uniquely dependent on mitochondrial respiration. It may be triggered by copper overload from either direct copper ion treatment or copper ionophores that shuttle Cu into cells. Copper binds directly to lipoylated proteins in the tricarboxylic acid (TCA) cycle, causing abnormal protein aggregation and proteotoxic stress. This results in the downregulation of iron-sulfur (Fe-S) cluster proteins and a loss of key metabolic enzymes. Cuproptosis only occurs in cells that rely on mitochondrial oxidative phosphorylation.

A ready-to-use Human Cuproptosis PCR primer library that may be used to set up to 100 PCR arrays. Contains 96 primer sets directed against cuproptosis genes.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



GENE LIST:

ABCA7 ATP binding cassette subfamily A member 7 NCBI+1

ADAM17 ADAM metallopeptidase domain 17 NCBI+1

ADAM9 ADAM metallopeptidase domain 9 (typical naming pattern)

AFP Alpha-fetoprotein

ALB Albumin

APP Amyloid precursor protein

AQP1 Aquaporin 1

ATOX1 Antioxidant protein 1

ATP7A ATPase copper transporting alpha

ATP7B ATPase copper transporting beta

BCL3 B-cell CLL/lymphoma 3

BCS1L BCS1 homolog, ubiquinolcytochrome c reductase complex chaperone

BIN1 Bridging integrator 1

BIRC2 Baculoviral IAP repeat containing 2

BTLA B- and T-lymphocyte attenuator

CASP2 Caspase 2

CD274 CD274 molecule (PD-L1)

CD2AP CD2 associated protein

CD33 CD33 molecule

CDK1 Cyclin dependent kinase 1

CDKN2A Cyclin dependent kinase inhibitor 2A

CELF1 CUGBP Elav-like family member 1

CLU Clusterin

COA6 Cytochrome c oxidase assembly factor 6

COX11 Cytochrome c oxidase copper chaperone

COX17 Cytochrome c oxidase copper chaperone COX17

COX19 COX19 cytochrome c oxidase assembly factor

COX23 Cytochrome c oxidase assembly factor 23

CP Ceruloplasmin

CT47A1 Cancer/testis antigen 47 A1

CTR1 Copper transporter 1

DBT Dihydrolipoamide branched chain transacylase E2

DLAT Dihydrolipoamide S-acetyltransferase

DLD Dihydrolipoamide dehydrogenase

DLST Dihydrolipoamide S-succinyltransferase

DNM1 Dynamin 1

EPHA1 EPH receptor A1

FADD Fas-associated via death domain

FDX1 Ferredoxin 1

GCSH Glycine cleavage system protein H

GLS Glutaminase

GPC1 Glypican 1

GPX4 Glutathione peroxidase 4

INPP5D Inositol polyphosphate-5-phosphatase D

ISCU Ironsulfur cluster assembly scaffold

ITGB6 Integrin subunit beta 6

KCNA3 Potassium voltage-gated channel subfamily A member 3

LIAS Lipoic acid synthetase

LIPT1 Lipoyltransferase 1

LOX Lysyl oxidase

LOXL2 Lysyl oxidase-like 2

MAP2K1 Mitogen-activated protein kinase kinase 1

MAPT Microtubule associated protein tau

MEF2C Myocyte enhancer factor 2C

MS4A6A Membrane spanning 4-domains A6A

MT2A Metallothionein 2A

MTCO1 Mitochondrially encoded cytochrome c oxidase I

MTCO2 Mitochondrially encoded cytochrome c oxidase II

MTF1 Metal regulatory transcription factor 1

NDUFC1 NADH:Ubiquinone oxidoreductase subunit C1

NFU1 NFU1 iron-sulfur cluster scaffold homolog

NPLOC4 Nuclear protein localization 4 homolog

OGDH Oxoglutarate dehydrogenase

PAM Peptidylglycine alpha-amidating monooxygenase

PDE3B Phosphodiesterase 3B

PDHA1 Pyruvate dehydrogenase E1 subunit alpha 1

PDHB Pyruvate dehydrogenase E1 subunit beta

PDHX Pyruvate dehydrogenase complex component X

PDK1 Pyruvate dehydrogenase kinase 1

PDX1 Pancreatic and duodenal homeobox 1

PICALM Phosphatidylinositol binding clathrin assembly protein

PRRX1 Paired related homeobox 1

PSEN1 Presenilin 1

PTK2B Protein tyrosine kinase 2 beta

SCO1 SCO copper chaperone 1

SCO2 SCO copper chaperone 2

SIRT2 Sirtuin 2

SLC31A1 Solute carrier family 31 member 1

SLC31A2 Solute carrier family 31 member 2

SOD1 Superoxide dismutase 1

SOD2 Superoxide dismutase 2

SOD3 Superoxide dismutase 3

SORL1 Sortilin-related receptor, L(DLR class), 1

STEAP3 STEAP3 metalloreductase

TMPRSS6 Transmembrane serine protease 6

TRADD TNF receptor type 1associated DEATH domain protein

TREM2 Triggering receptor expressed on myeloid cells 2

VCP Valosin containing protein

ACTB Actin, beta

B2M Beta-2-microglobulin

GAPD Glyceraldehyde-3-phosphate dehydrogenase

GUSB Glucuronidase, beta

HPRT1 Hypoxanthine phosphoribosyltransferase 1

PGK Phosphoglycerate kinase 1

PPIA Peptidylprolyl isomerase A

RPL13A Ribosomal protein L13a

$495.00
HCUP-I
A ready-to-use Mouse Cuproptosis PCR primer library that may be used to set up to 100 PCR arrays. Contains 88 primer sets directed against cuproptosis genes and 8 housekeeping gene primer sets.

Provided in a 96-well microplate (20 ul - 10 uM)

Perform up to 100 PCR arrays (based on 20 ul assay volume per reaction)

Just add cDNA template and SYBR green master mix



GENE LIST:

Abca7 ATP-binding cassette, sub-family A member 7

Adam17 a disintegrin and metallopeptidase domain 17

Adam9 a disintegrin and metallopeptidase domain 9

Afp alpha fetoprotein

Alb albumin

App amyloid beta precursor protein

Aqp1 aquaporin 1

Atox1 antioxidant 1 copper chaperone

Atp7a ATPase, Cu++ transporting, alpha polypeptide

Atp7b ATPase, Cu++ transporting, beta polypeptide

Bcl3 B cell leukemia/lymphoma 3

Bcs1l BCS1-like (yeast)

Bin1 bridging integrator 1

Birc2 baculoviral IAP repeat-containing 2

Btla B and T lymphocyte associated

Casp2 caspase 2

Cd274 CD274 antigen (PD-L1)

Cd2ap CD2-associated protein

Cd33 CD33 antigen

Cdk1 cyclin-dependent kinase 1

Cdkn2a cyclin dependent kinase inhibitor 2A

Celf1 CUGBP, Elav-like family member 1

Clu clusterin

Coa6 cytochrome c oxidase assembly factor 6

Cox11 cytochrome c oxidase assembly protein 11

Cox17 cytochrome c oxidase assembly protein 17, copper chaperone

Cox19 cytochrome c oxidase assembly protein 19

Chchd7 coiled-coil-helix-coiled-coil-helix domain containing 7 (COX23)

Cp ceruloplasmin

CT47A1 cancer/testis antigen family 47 member A1 (human gene, no mouse ortholog)

Slc31a1 solute carrier family 31, member 1 (CTR1)

Dbt dihydrolipoamide branched chain transacylase E2

Dlat dihydrolipoamide S-acetyltransferase

Dld dihydrolipoamide dehydrogenase

Dlst dihydrolipoamide S-succinyltransferase

Dnm1 dynamin 1

Epha1 Eph receptor A1

Fadd Fas (TNFRSF6)-associated via death domain

Fdx1 ferredoxin 1

Gcsh glycine cleavage system protein H (aminomethyl carrier)

Gls glutaminase

Gpc1 glypican 1

Gpx4 glutathione peroxidase 4

Inpp5d inositol polyphosphate-5-phosphatase D

Iscu iron-sulfur cluster assembly enzyme

Itgb6 integrin beta 6

Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3

Lias lipoic acid synthetase

Lipt1 lipoyltransferase 1

Lox lysyl oxidase

Loxl2 lysyl oxidase-like 2

Map2k1 mitogen-activated protein kinase kinase 1

Mapt microtubule-associated protein tau

Mef2c myocyte enhancer factor 2C

Ms4a6b membrane-spanning 4-domains, subfamily A, member 6B

Mt2 metallothionein 2

mt-Co1 mitochondrially encoded cytochrome c oxidase I

mt-Co2 mitochondrially encoded cytochrome c oxidase II

Mtf1 metal response element binding transcription factor 1

Ndufc1 NADH:ubiquinone oxidoreductase subunit C1

Nfu1 NFU1 iron-sulfur cluster scaffold

Nploc4 NPL4 homolog, ubiquitin recognition factor

Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase

Pam peptidylglycine alpha-amidating monooxygenase

Pde3b phosphodiesterase 3B, cGMP-inhibited

Pdha1 pyruvate dehydrogenase E1 alpha 1

Pdhb pyruvate dehydrogenase (lipoamide) beta

Pdhx pyruvate dehydrogenase complex, component X

Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1

Pdx1 pancreatic and duodenal homeobox 1

Picalm phosphatidylinositol binding clathrin assembly protein

Prrx1 paired related homeobox 1

Psen1 presenilin 1

Ptk2b PTK2 protein tyrosine kinase 2 beta

Sco1 SCO1 cytochrome c oxidase assembly protein

Sco2 SCO2 cytochrome c oxidase assembly protein

Sirt2 sirtuin 2

Slc31a1 solute carrier family 31, member 1

Slc31a2 solute carrier family 31, member 2

Sod1 superoxide dismutase 1, soluble

Sod2 superoxide dismutase 2, mitochondrial

Sod3 superoxide dismutase 3, extracellular

Sorl1 sortilin-related receptor, LDLR class A repeats-containing

Steap3 STEAP family member 3

Tmprss6 transmembrane serine protease 6

Tradd TNFRSF1A-associated via death domain

Trem2 triggering receptor expressed on myeloid cells 2

Vcp valosin containing protein

Actb Actin, beta

B2m Beta-2-microglobulin

Gapdh Glyceraldehyde-3-phosphate dehydrogenase

Gusb Glucuronidase, beta

Hprt Hypoxanthine phosphoribosyltransferase 1

Pgk1 Phosphoglycerate kinase 1

Ppia Peptidylprolyl isomerase A

Rpl13a Ribosomal protein L13a
$495.00
MCUP-I